Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated?
نویسندگان
چکیده
منابع مشابه
The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.
Toll-like receptor (TLR) ligands that signal via TIR-domain-containing adapter-inducing IFNβ (TRIF) activate the IκB kinase (IKK)-related kinases, TRAF associated NFκB activator (TANK)-binding kinase-1 (TBK1) and IKKε, which then phosphorylate IRF3 and induce the production of IFNβ. Here we show that TBK1 and IKKε are also activated by TLR ligands that signal via MyD88. Notably, the activation ...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2008
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2008.01.002